2022/09/09 by Wendy Groenendijk, Wendy N. Groenendijk, Delia Bogdanet +18
Medicine · #Anthropometry #Body mass index #Cancer Risks and Factors #Clinical Laboratory Practices and Quality Control #Gestational age #Gynecology #Hematology #Internal medicine #Medicine #Obstetrics #Pregnancy #Pregnancy and preeclampsia studies #Prospective cohort study
paper · doi:10.1177/00045632221128686
openalex publication_date 2022/09/09 · crossref created 2022/09/09 · crossref issued 2022/10/04 · crossref published 2022/10/04 · crossref published-online 2022/10/04 · crossref published-print 2022/11/01 · openalex created_date 2025/10/10 · crossref deposited 2026/04/28 · crossref indexed 2026/08/03 · openalex updated_date 2026/08/03
BACKGROUND: Pregnancy induces physiological changes which affect biochemical and haematological parameters. As the significance of laboratory test results change throughout pregnancy, the reference interval (RI) or key result interpretive guide should be specific to pregnancy. This study sought to establish trimester-specific-RIs for routine biochemical and haematological tests in healthy white European women with singleton pregnancies with comparison to RIs for non-pregnant European adults. METHODS: A retrospective analysis of a prospective longitudinal single-centre study of healthy pregnant women conducted between November 2018 and December 2020 in a tertiary academic hospital with approximately 3000 births annually. Inclusion criteria: signed informed consent, age ≥18 years, white European, body mass index (BMI) <25 kg/m2, blood pressure <140/90mmHg, non-smoker, no previous pathology or gestational diabetes. Trimester defined as T1: up to 13 weeks + 6 days, T2: 14-27 weeks + 6 days and T3: ≥28-41 weeks + 6 days. Baseline demographics, anthropometric and laboratory measurements were recorded. In total, 31 biochemical and 10 haematological ISO15189:2012 accredited tests were measured using Roche Cobas® and Sysmex XN-9100™ analysers, respectively. RIs were established according to the International Federation of Clinical Chemistry (IFCC) recommended method. RESULTS: and systolic and diastolic blood pressure of 116 (110-125) mmHg and 67 (61-75) mmHg, respectively. CONCLUSIONS: Normative trimester-specific biological intervals for routinely requested biochemical and haematological medical laboratory tests were established. These RIs will be invaluable to result interpretation and the management of pregnant women.