Experimental Fasciola hepatica Infection Alters Responses to Tests Used for Diagnosis of Bovine Tuberculosis

2006/12/29 by Robin J. Flynn, C. Mannion, Celine Mannion +4 · 27 citations
Immunology and Microbiology · Medicine · Veterinary · #Antigen #Biology #Coinfection #Disease #Fasciola hepatica #Helminth infection and control #Helminths #Hepatica #Human immunodeficiency virus (HIV) #Immune system #Immunology #Internal medicine #Medicine #Mycobacterium bovis #Mycobacterium tuberculosis #Parasites and Host Interactions #Pathology #Tuberculosis #Tuberculosis Research and Epidemiology #Virology

paper · doi:10.1128/iai.01445-06

openalex publication_date 2006/12/29 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/22

Abstract

Fasciola hepatica is a prevalent helminth parasite of livestock. Infection results in polarization of the host's immune response and generation of type 2 helper (Th2) immune responses, which are known to be inhibitory to Th1 responses. Bovine tuberculosis (BTB) is a bacterial disease of economic and zoonotic importance. Control polices for this disease rely on extensive annual testing and a test-and-slaughter policy. The correct diagnosis of BTB relies on cell-mediated immune responses. We established a model of coinfection of F. hepatica and Mycobacterium bovis BCG to examine the impact of helminth infection on correct diagnosis. We found the predictive capacity of tests to be compromised in coinfected animals and that F. hepatica infection altered macrophage function. Interleukin-4 and gamma interferon expression in whole-blood lymphocytes restimulated in vitro with M. bovis antigen was also altered in coinfected animals. These results raise the question of whether F. hepatica infection can affect the predictive capacity of tests for the diagnosis of BTB and possibly also influence susceptibility to BTB and other bacterial diseases. Further studies on the interplay between helminth infection and BTB are warranted.

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• Comparative transcriptome profiling approach to glean virulence and immunomodulation-related genes of Fasciola hepatica. [europepmc]
• Fasciola hepatica infection reduces Mycobacterium bovis burden and mycobacterial uptake and suppresses the pro-inflammatory response. [europepmc]
• Transcriptomic responses of water buffalo liver to infection with the digenetic fluke Fasciola gigantica. [europepmc]
• Fasciola hepatica reinfection potentiates a mixed Th1/Th2/Th17/Treg response and correlates with the clinical phenotypes of anemia. [europepmc]
• Immune signatures of pathogenesis in the peritoneal compartment during early infection of sheep with Fasciola hepatica. [europepmc]
• Recombinant Fasciola hepatica fatty acid binding protein suppresses toll-like receptor stimulation in response to multiple bacterial ligands. [europepmc]
• Dairy Heifers Naturally Exposed to Fasciola hepatica Develop a Type 2 Immune Response and Concomitant Suppression of Leukocyte Proliferation. [europepmc]
• Dynamic expression of cytokine and transcription factor genes during experimental Fasciola gigantica infection in buffaloes. [europepmc]
• Bovine tuberculosis visible lesions in cattle culled during herd breakdowns: the effects of individual characteristics, trade movement and co-infection. [europepmc]
• Bovine Tuberculosis in Britain and Ireland - A Perfect Storm? the Confluence of Potential Ecological and Epidemiological Impediments to Controlling a Chronic Infectious Disease. [europepmc]
• Association of Fasciola gigantica Co-infection With Bovine Tuberculosis Infection and Diagnosis in a Naturally Infected Cattle Population in Africa. [europepmc]
• Efficacy and Safety of BCG Vaccine for Control of Tuberculosis in Domestic Livestock and Wildlife. [europepmc]
• The Influence of Parasite Infections on Host Immunity to Co-infection With Other Pathogens. [europepmc]
• Fh15 Blocks the Lipopolysaccharide-Induced Cytokine Storm While Modulating Peritoneal Macrophage Migration and CD38 Expression within Spleen Macrophages in a Mouse Model of Septic Shock. [europepmc]
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• Genome-wide associations and functional gene analyses for endoparasite resistance in an endangered population of native German Black Pied cattle. [europepmc]
• Co-infection of cattle with Fasciola hepatica or F. gigantica and Mycobacterium bovis: A systematic review. [europepmc]
• Interactions between helminths and tuberculosis infections: Implications for tuberculosis diagnosis and vaccination in Africa. [europepmc]
• Evaluation of the Efficacy of BCG in Protecting Against Contact Challenge With Bovine Tuberculosis in Holstein-Friesian and Zebu Crossbred Calves in Ethiopia. [europepmc]

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