LSH hamster model of syphilitic infection

1980/06/01 by R F Schell, Ronald F. Schell, Jack L. LeFrock +5 · 4 citations
Medicine · Immunology and Microbiology · #Syphilis Diagnosis and Treatment #Reproductive tract infections research #Reproductive System and Pregnancy

paper · doi:10.1128/iai.28.3.909-913.1980

Abstract

The inbred LSH/Se LAK strain of hamster can be infected with Treponema pallidum Bosnia A, the causative agent of endemic syphilis. When infected, this strain consistently produced extensive chronic skin lesions that persisted for 6 to 9 months, even in the presence of peak antitreponemal antibody titers. The lymph nodes increased in weight and contained measurable numbers of treponemes. This infection also gave the hamster cross-immunity to T. pallidum Nichols and Treponema pertenue, the causative agents of venereal syphilis and frambesia, respectively. LSH hamsters are thus an excellent model to study the immune response mechanisms to syphilitic infection.

Cited by

• Resurgence of syphilis: focusing on emerging clinical strategies and preclinical models. [europepmc]
• Immunity to Sexually Transmitted Bacterial Infections of the Female Genital Tract: Toward Effective Vaccines. [europepmc]
• Research Advances in Clinical Strategies and Preclinical Models for Syphilis Relapse. [europepmc]
• The Experimental Use of Syrian Hamsters [europepmc]

Related

• Syphilis Pathogenesis: Host Immune Response vs Pathogen Immune Evasion
• <i>Treponema pallidum</i>subsp.<i>pertenue</i>Displays Pathogenic Properties Different from Those of<i>T. pallidum</i>subsp.<i>pallidum</i>
• Cultivation of Virulent <i>Treponema pallidum</i> in Tissue Culture
• Intrinsic differences in hamster and mouse macrophage biology correlate with susceptibility to <i>Leishmania donovani</i> infection
• A case of a pseudoneoplastic primary syphilis chancre on the neck