Oxygen Uptake by Treponema pallidum

1974/07/01 by C. D. Cox, Charles D. Cox, M. K. Barber · 6 citations
Immunology and Microbiology · Nursing · Pharmacology, Toxicology and Pharmaceutics · #Neutrophil, Myeloperoxidase and Oxidative Mechanisms #Vitamin C and Antioxidants Research #Bioactive Compounds and Antitumor Agents

paper · pdf · doi:10.1128/iai.10.1.123-127.1974

Abstract

Virulent Treponema pallidum has been shown to consume O(2) at a rate similar to that of the known aerobic spirochaete, Leptospira. Such O(2) uptake is cyanide sensitive, indicating a functioning cytochrome oxidase. Inhibition of O(2) uptake by azide, chlorpromazine, and amytal further suggests a functioning electron transport system for the oxidation of nicotinamide adenine dinucleotide (reduced) to O(2). Evidence is consistent with the probability that this terminal electron-transport system is coupled to oxidative phosphorylation. The potential significance of these findings is discussed.

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