Comparison of the Host Responses to Wild-Type and<i>cpsB</i>Mutant<i>Klebsiella pneumoniae</i>Infections

2006/08/22 by Matthew S. Lawlor, Scott A. Handley, Virginia L. Miller · 26 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #Antibiotic Resistance in Bacteria #Immune Response and Inflammation #Bacterial Infections and Vaccines

paper · doi:10.1128/iai.00244-06

Abstract

Previously, we established an intranasal mouse model of Klebsiella pneumoniae infection and validated its utility using a highly virulent wild-type strain and an avirulent capsular polysaccharide mutant. In the present study we compare the host responses to both infections by examining cytokine production, cellular infiltration, pulmonary histology, and intranasal immunization.

Cited by

• Connections between <i>Klebsiella pneumoniae</i> bloodstream dynamics and serotype-independent capsule properties
• Complete Genome Sequence of Klebsiella pneumoniae Strain ATCC 43816 KPPR1, a Rifampin-Resistant Mutant Commonly Used in Animal, Genetic, and Molecular Biology Studies. [europepmc]
• Porin Loss Impacts the Host Inflammatory Response to Outer Membrane Vesicles of Klebsiella pneumoniae. [europepmc]
• Klebsiella pneumoniae: Going on the Offense with a Strong Defense. [europepmc]
• Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-β Synthesis Induced by Lipopolysaccharide. [europepmc]
• A Serendipitous Mutation Reveals the Severe Virulence Defect of a Klebsiella pneumoniae fepB Mutant. [europepmc]
• High Levels of Cyclic Di-GMP in Klebsiella pneumoniae Attenuate Virulence in the Lung. [europepmc]
• Pseudomonas aeruginosa and Klebsiella pneumoniae Adaptation to Innate Immune Clearance Mechanisms in the Lung. [europepmc]
• Identification of Two Regulators of Virulence That Are Conserved in Klebsiella pneumoniae Classical and Hypervirulent Strains. [europepmc]
• Klebsiella pneumoniae infection biology: living to counteract host defences. [europepmc]
• Risk factors for the first episode of Acinetobacter baumannii resistant to colistin infection and outcome in critically ill patients. [europepmc]
• Hypervirulent Klebsiella pneumoniae - clinical and molecular perspectives. [europepmc]
• Targeting the Sugary Armor of Klebsiella Species. [europepmc]
• A Porcine Ex Vivo Lung Perfusion Model To Investigate Bacterial Pathogenesis. [europepmc]
• Bacteriophages of Klebsiella spp., their diversity and potential therapeutic uses. [europepmc]
• Transposon Mutagenesis Screen of Klebsiella pneumoniae Identifies Multiple Genes Important for Resisting Antimicrobial Activities of Neutrophils in Mice. [europepmc]
• The intersection of capsule gene expression, hypermucoviscosity and hypervirulence in Klebsiella pneumoniae. [europepmc]
• A murine model demonstrates capsule-independent adaptive immune protection in survivors of Klebsiella pneumoniae respiratory tract infection. [europepmc]
• Target the Host, Kill the Bug; Targeting Host Respiratory Immunosuppressive Responses as a Novel Strategy to Improve Bacterial Clearance During Lung Infection. [europepmc]
• Animal Model To Study Klebsiella pneumoniae Gastrointestinal Colonization and Host-to-Host Transmission. [europepmc]
• The KbvR Regulator Contributes to Capsule Production, Outer Membrane Protein Biosynthesis, Antiphagocytosis, and Virulence in Klebsiella pneumoniae. [europepmc]
• From Klebsiella pneumoniae Colonization to Dissemination: An Overview of Studies Implementing Murine Models. [europepmc]
• Resistance of Dickeya solani strain IPO 2222 to lytic bacteriophage ΦD5 results in fitness tradeoffs for the bacterium during infection. [europepmc]
• Recombinase-Aided Amplification Assay for Rapid Detection of Hypervirulent Klebsiella pneumoniae (hvKp) and Characterization of the hvKp Pathotype. [europepmc]
• General Overview of Klebsiella pneumonia : Epidemiology and the Role of Siderophores in Its Pathogenicity. [europepmc]
• Capsular polysaccharide enables Klebsiella pneumoniae to evade phagocytosis by blocking host-bacteria interactions. [europepmc]

Related

• Divergent humoral immune signatures in response to Klebsiella pneumoniae bacteremia
• Genetic exchange of determinants for capsular polysaccharide biosynthesis between Klebsiella pneumoniae strains expressing serotypes K2 and K21a
• Carbapenem-Resistant Klebsiella pneumoniae Exhibit Variability in Capsular Polysaccharide and Capsule Associated Virulence Traits
• Connections between <i>Klebsiella pneumoniae</i> bloodstream dynamics and serotype-independent capsule properties
• Hypermucoviscosity in Klebsiella pneumoniae : manifestation, regulation, and roles in pathogenesis