In Vitro Selection Identifies Staphylococcus aureus Genes Influencing Biofilm Formation

2023/02/27 by Dustin R. Long, Kelsi Penewit, Hsin‐Yu Lo +9 · 16 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Antimicrobial Resistance in Staphylococcus #Bacteria #Bacterial biofilms and quorum sensing #Biofilm #Biology #Gene #Genetics #In vitro #Microbiology #Selection (genetic algorithm) #Staphylococcal infections #Staphylococcus aureus

paper · open access · doi:10.1128/iai.00538-22

published in Infection and Immunity 91(3), e0053822 (American Society for Microbiology)

openalex publication_date 2023/02/27 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Staphylococcus aureus generates biofilms during many chronic human infections, which contributes to its growth and persistence in the host. Multiple genes and pathways necessary for S. aureus biofilm production have been identified, but knowledge is incomplete, and little is known about spontaneous mutations that increase biofilm formation as infection progresses.

Citations

• Basic local alignment search tool

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