Local Chemokine Paralysis, a Novel Pathogenic Mechanism forPorphyromonas gingivalis

1998/04/01 by Richard P. Darveau, Carol M. Belton, Robert A. Reife +1 · 33 citations
Dentistry · Medicine · #Oral microbiology and periodontitis research #Streptococcal Infections and Treatments #Oral Health Pathology and Treatment

paper · pdf · doi:10.1128/iai.66.4.1660-1665.1998

Abstract

Periodontitis, which is widespread in the adult population, is a persistent bacterial infection associated with Porphyromonas gingivalis. Gingival epithelial cells are among the first cells encountered by both P. gingivalis and commensal oral bacteria. The chemokine interleukin 8 (IL-8), a potent chemoattractant and activator of polymorphonuclear leukocytes, was secreted by gingival epithelial cells in response to components of the normal oral flora. In contrast, P. gingivalis was found to strongly inhibit IL-8 accumulation from gingival epithelial cells. Inhibition was associated with a decrease in mRNA for IL-8. Antagonism of IL-8 accumulation did not occur in KB cells, an epithelial cell line that does not support high levels of intracellular invasion by P. gingivalis. Furthermore, a noninvasive mutant of P. gingivalis was unable to antagonize IL-8 accumulation. Invasion-dependent destruction of the gingival IL-8 chemokine gradient at sites of P. gingivalis colonization (local chemokine paralysis) will severely impair mucosal defense and represents a novel mechanism for bacterial colonization of host tissue.

Citations

• Ability of bacteria associated with chronic inflammatory disease to stimulate E-selectin expression and promote neutrophil adhesion

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• Chemokines in Oral Inflammatory Diseases: Apical Periodontitis and Periodontal Disease
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• The Keystone‐Pathogen Hypothesis Updated: The Role of Porphyromonas gingivalis in Periodontitis
• Polymicrobial communities in periodontal disease: Their quasi‐organismal nature and dialogue with the host
• Akkermansia muciniphila enhances mucosal immunity against porphyromonas gingivalis
• Induction of interleukin (IL)‐1β, IL‐10, IL‐8 and immunoglobulin G by Porphyromonas gingivalis HmuY in humans
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• Relationships between subgingival microbiota and GCF biomarkers in generalized aggressive periodontitis. [europepmc]
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• Contribution of Porphyromonas gingivalis lipopolysaccharide to periodontitis. [europepmc]
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• Polymicrobial communities in periodontal disease: Their quasi-organismal nature and dialogue with the host. [europepmc]
• Local and Systemic Effects of Porphyromonas gingivalis Infection. [europepmc]

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• The Role of Porphyromonas gingivalis Outer Membrane Vesicles in Periodontal Disease and Related Systemic Diseases
• Role of Porphyromonas gingivalis SerB in Gingival Epithelial Cell Cytoskeletal Remodeling and Cytokine Production
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