2007/12/31 by Debashish Chowdhury, Ashok Garai, Jian‐Sheng Wang +1 · 2 citations
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #Diffusion and Search Dynamics #Microtubule and mitosis dynamics #cond-mat.stat-mech #physics.bio-ph #q-bio.SC #stochastic dynamics and bifurcation
paper · pdf · doi:10.1103/physreve.77.050902
published as Physical Review E (Rapid Communication), vol.77, 050902 (R), (2008) · 4 pages REVTEX with 4 EPS figures; new schematic figure of the model
arxiv created 2008/04/17 · openalex publication_date 2008/05/12 · arxiv updated 2009/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04
KIF1A kinesins are single-headed motor proteins which move on cylindrical nanotubes called microtubules (MTs). A normal MT consists of 13 protofilaments on which the equispaced motor binding sites form a periodic array. The collective movement of the kinesins on a MT is, therefore, analogous to vehicular traffic on multilane highways where each protofilament is the analog of a single lane. Does lane changing increase or decrease the motor flux per lane? We address this fundamental question here by appropriately extending a recent model [P. Greulich, Phys. Rev. E 75, 041905 (2007)]. By carrying out analytical calculations and computer simulations of this extended model, we predict that the flux per lane can increase or decrease with the increasing rate of lane changing, depending on the concentrations of motors and the rate of hydrolysis of ATP, the "fuel" molecules. Our predictions can be tested, in principle, by carrying out in vitro experiments with fluorescently labeled KIF1A molecules.