Radicals: Reactive Intermediates with Translational Potential

2016/09/15 by Ming Yan, Julian C. Lo, Jacob T. Edwards +1 · 1 citation
Chemistry · #Click Chemistry and Applications #Free Radicals and Antioxidants #Radical Photochemical Reactions

paper · doi:10.1021/jacs.6b08856

openalex publication_date 2016/09/15 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

This Perspective illustrates the defining characteristics of free radical chemistry, beginning with its rich and storied history. Studies from our laboratory are discussed along with recent developments emanating from others in this burgeoning area. The practicality and chemoselectivity of radical reactions enable rapid access to molecules of relevance to drug discovery, agrochemistry, material science, and other disciplines. Thus, these reactive intermediates possess inherent translational potential, as they can be widely used to expedite scientific endeavors for the betterment of humankind.

Citations

• Rate Constants for Reactions of Aliphatic Carbon-Centered Radicals in Aqueous Solution
• C−H Activation for the Construction of C−B Bonds
• Boron: A key element in radical reactions
• The Persistent Radical Effect: A Principle for Selective Radical Reactions and Living Radical Polymerizations
• Scalable enantioselective total synthesis of taxanes
• The persistent radical effect: a prototype example of extreme, 105 to 1, product selectivity in a free-radical reaction involving persistent .cntdot.CoII[macrocycle] and alkyl free radicals
• Methods of Reactivity Umpolung
• Diterpenoids from Isodon species and their biological activities
• Short, Enantioselective Total Synthesis of Highly Oxidized Taxanes
• THE RELATIVE STABILITY OF PENTAARYLETHANES. III.1 THE REVERSIBLE DISSOCIATION OF PENTAARYLETHANES*
• Mechanisms of free-radical aromatic substitution
• Unusual selectivities of radical reactions by internal suppression of fast modes

Cited by

• Persistent radical effect [wikipedia]