Polytriazoles as Copper(I)-Stabilizing Ligands in Catalysis

2004/07/30 by Timothy R. Chan, Robert Hilgraf, K. Barry Sharpless +1 · 3 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Advanced biosensing and bioanalysis techniques #Chemical Synthesis and Analysis #Click Chemistry and Applications

paper · doi:10.1021/ol0493094

openalex publication_date 2004/07/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes. The C3-symmetric derivative, TBTA, was shown to be a powerful stabilizing ligand for copper(I), protecting it from oxidation and disproportionation, while enhancing its catalytic activity.

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