2007/02/01 by Franck Suzenet, Nicolas Leconte, Anne Keromnes‐Wuillaume +1 · 1 citation
Chemistry · #Synthesis and Biological Evaluation #Synthesis and Characterization of Heterocyclic Compounds #Click Chemistry and Applications
paper · doi:10.1055/s-2007-967991
openalex publication_date 2007/02/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/11
Palladium-catalyzed copper(I)-mediated cross-coupling reaction of 3-methylthio-6-(morpholin-4-yl)-1,2,4,5-tetrazine with a wide range of boronic acids and organotin derivatives led to new unsymmetrical aryl- and hetaryl-substituted tetrazines in moderate to good yields. These results represent the first cross-coupling reactions of readily available 3-methylthiotetrazine under Suzuki-like and Stille-like conditions and could extend the scope of tetrazine chemistry.