Direct Addition of TMS-acetylene to Aldimines Catalyzed by a Simple, Commercially Available Ir(I) Complex

2001/11/22 by Christian A. Fischer, Erick M. Carreira · 4 citations
Chemistry · #Catalytic Cross-Coupling Reactions #Catalytic C–H Functionalization Methods #Synthetic Organic Chemistry Methods

paper · doi:10.1021/ol017022q

openalex publication_date 2001/11/22 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/26

Abstract

A new, convenient procedure for the addition reaction of trimethylsilylacetylene to imines is described. Simply treating a solution of aldimine and trimethylsilyl acetylene with catalytic [IrCl(COD)](2) furnishes the adduct in preparatively useful yields. Interestingly, the reaction may be conducted in the absence of solvent. [reaction: see text]

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