2004/11/26 by José M. Alonso, Anna N. Stepanova · 227 citations
Agricultural and Biological Sciences · Chemistry · #Arabidopsis #Biochemistry #Biology #Cell biology #Cell signaling #Chemistry #Computational biology #Gene #Mutant #Plant Physiology and Cultivation Studies #Plant responses to water stress #Postharvest Quality and Shelf Life Management #Signal transduction #Ubiquitin
paper · doi:10.1126/science.1104812
published in Science 306(5701), 1513-1515 (American Association for the Advancement of Science)
openalex publication_date 2004/11/26 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/06
Plants use a structurally very simple gas molecule, the hydrocarbon ethylene, to modulate various developmental programs and coordinate responses to a multitude of external stress factors. How this simple molecule generates such a diverse array of effects has been the subject of intense research for the past two decades. A fascinating signaling pathway, with classical as well as novel plant-specific signaling elements, is emerging from these studies. We describe the four main modules that constitute this signaling pathway: a phosphotransfer relay, an EIN2-based unit, a ubiquitin-mediated protein degradation component, and a transcriptional cascade. The canonical and Arabidopsis ethylene signaling pathways in the Signal Transduction Knowledge Environment Connections Maps provide a complete panoramic view of these signaling events in plants.