Catalytic CF Activation and Hydrodefluorination of Fluoroalkyl Groups

2009/01/15 by Gregor Meier, Thomas Braun · 2 citations
Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Carborane #Catalysis #Catalytic cycle #Cationic polymerization #Chemistry #Fluoride #Fluorine in Organic Chemistry #Halogenation #Inorganic Fluorides and Related Compounds #Inorganic chemistry #Medicinal chemistry #Organic chemistry #Organoboron and organosilicon chemistry #Photochemistry #Polymer chemistry #Silylation

paper · doi:10.1002/anie.200805237

openalex publication_date 2009/01/15 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/26

Abstract

A powerful fluoride trap: The extremely Lewis acidic silyl cation [Et(3)Si](+) is an active catalyst for the hydrodefluorination of fluoroalkyl groups at room temperature (see example). The carborane anion [CHB(11)H(5)Cl(6)](-) plays an essential role in the catalytic cycle as a weakly coordinating anion that stabilizes cationic intermediates.

Citations

• Activation of Carbon-Fluorine Bonds by Metal Complexes

Cited by

• Synthesis of Fluorinated Building Blocks by Transition‐Metal‐Mediated Hydrodefluorination Reactions
• Hydrodefluorination [wikipedia]

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