Asymmetric Ion‐Pairing Catalysis

2012/11/28 by Katrien Brak, Eric N. Jacobsen · 2 citations
Chemical Engineering · Chemistry · #Asymmetric Hydrogenation and Catalysis #Asymmetric Synthesis and Catalysis #Ionic liquids properties and applications

paper · doi:10.1002/anie.201205449

openalex publication_date 2012/11/28 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30

Abstract

Charged intermediates and reagents are ubiquitous in organic transformations. The interaction of these ionic species with chiral neutral, anionic, or cationic small molecules has emerged as a powerful strategy for catalytic, enantioselective synthesis. This review describes developments in the burgeoning field of asymmetric ion-pairing catalysis with an emphasis on the insights that have been gleaned into the structural and mechanistic features that contribute to high asymmetric induction.

Citations

• Efficient catalytic asymmetric alkylations. 1. Enantioselective synthesis of (+)-indacrinone via chiral phase-transfer catalysis
• Recent Development and Application of Chiral Phase-Transfer Catalysts
• Chiral Phosphoric Acids as Versatile Catalysts for Enantioselective Transformations
• Chiral Anion-Mediated Asymmetric Ring Opening of meso-Aziridinium and Episulfonium Ions
• Chiral crown complexes catalyse Michael addition reactions to give adducts in high optical yields
• A Novel Example of Chiral Counteranion Induced Enantioselective Metal Catalysis: The Importance of Ion-Pairing in Copper-Catalyzed Olefin Aziridination and Cyclopropanation

Cited by

• Enantioselective Aza-Sakurai Cyclizations: Dual Role of Thiourea as H-Bond Donor and Lewis Base
• Asymmetric ion-pairing catalysis [wikipedia]