1969/11/01 by Federico Arcamone, Giuseppe Cassinelli, G. Fantini +4 · 6 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Microbial Natural Products and Biosynthesis #Synthesis and Biological Activity #Synthetic Organic Chemistry Methods
paper · doi:10.1002/bit.260110607
openalex publication_date 1969/11/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/11
Abstract Streptomyces peucetius var. caesius , obtained from S. peucetius , the daunomycin producing microorganism, by mutagenic treatment, differs from the parent culture by the color of the vegetative and aerial mycelia and by its antibiotic, producing ability. S. peucetius var. caesius accumulates adriamycin in submerged and aerated culture on a medium containing glucose, brewer's yeast, and inorganic, salts both in shake flasks and in stirred fementers. Isolation of the product is performed by solvent extraction, chromatography on buffered cellulose columns, and crystallization as the hydrochloride. The new antitumor agent, adriamycin, is the 14‐hydroxv derivative of daunomyein.