2007/08/14 by Anna Salvati, Sandra Ristori, Julian Oberdisse +5
Materials Science · Medicine · Physics and Astronomy · #Boron Compounds in Chemistry #Nanoparticle-Based Drug Delivery #Porphyrin and Phthalocyanine Chemistry #cond-mat.soft #physics.bio-ph
paper · pdf · doi:10.1021/jp0731710
published as The Journal of Physical Chemistry B 111 (2007) 10357-10364
openalex publication_date 2007/08/14 · arxiv created 2007/09/06 · arxiv updated 2009/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
In this work, the physicochemical characterization of liposomes loaded with a newly synthesized carboranyl porphyrazine (H2HECASPz) is described. This molecule represents a potential drug for different anticancer therapies, such as boron neutron capture therapy and for photodynamic therapy or photothermal therapy. Different loading methods and different lipid mixtures were tested. The corresponding loaded vectors were studied by small angle scattering, light scattering, and zeta potential. The combined analysis of structural data at various lengths of scales and the measurement of the surface charge allowed us to obtain a detailed characterization of the investigated systems. The mechanisms underlying the onset of differences in relevant physicochemical parameters (size, polydispersity, and charge) were also critically discussed.