2009/12/01 by Adriana Gibara Guimarães, Mônica Santos de Melo Seabra, Rangel R. Bonfim +6 · 1 citation
Medicine · Agricultural and Biological Sciences · #Inflammatory mediators and NSAID effects #Phytochemistry and Biological Activities #Essential Oils and Antimicrobial Activity
paper · pdf · doi:10.1590/s0102-695x2009000600016
openalex publication_date 2009/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23
Eugenia candolleana DC. (Myrtaceae), commonly known as "murta" or "murtinha", is a plant species without any chemical or pharmacological study described in the literature. It has been popularly used for the treatment of pain and fever. This report aimed to investigate the possible antinociceptive and anti-inflammatory effects of the essential oil extracted from fresh leaves of Eugenia candolleana DC. (EOEc) in rodents. Following intraperitoneal injection, EOEc (25, 50 and 100 mg/kg) reduced the number of writhes significantly in a writhing test and the number of paw licks during phase two of formalin test (p < 0.001). However, administration of EOEc did not alter the time of reaction in hot plate test. Furthermore, EOEc inhibited (p < 0.01) the carrageenan-induced leukocyte migration to the peritoneal cavity. These results indicate antinociceptive and anti-inflammatory properties of EOEc probably mediated via inhibition of prostaglandin synthesis or other peripherally pathway.