Synergistic catalysis: A powerful synthetic strategy for new reaction development

2012/01/01 by Anna Allen, David W. C. MacMillan · 2 citations
Chemistry · #Asymmetric Hydrogenation and Catalysis #Asymmetric Synthesis and Catalysis #Synthetic Organic Chemistry Methods

paper · doi:10.1039/c2sc00907b

openalex publication_date 2012/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04

Abstract

Synergistic catalysis is a synthetic strategy wherein both the nucleophile and the electrophile are simultaneously activated by two separate and distinct catalysts to afford a single chemical transformation. This powerful catalysis strategy leads to several benefits, specifically synergistic catalysis can (i) introduce new, previously unattainable chemical transformations, (ii) improve the efficiency of existing transformations, and (iii) create or improve catalytic enantioselectivity where stereocontrol was previously absent or challenging. This perspective aims to highlight these benefits using many of the successful examples of synergistic catalysis found in the literature.

Citations

• New synthetic reactions. Allylic alkylation
• Asymmetric Transition Metal-Catalyzed Allylic Alkylations
• Recent advances in Sonogashira reactions
• Organic syntheses by means of noble metal compounds XVII. Reaction of π-allylpalladium chloride with nucleophiles
• 3-Stannylcyclobutenediones as nucleophilic cyclobutenedione equivalents. Synthesis of substituted cyclobutenediones and cyclobutenedione monoacetals and the beneficial effect of catalytic copper iodide on the Stille reaction
• On the Nature of the "Copper Effect" in the Stille Cross-Coupling

Cited by

• Redox‐Neutral Copper(II) Carboxylate Catalyzed α‐Alkynylation of Amines
• Phosphonium coupling [wikipedia]