1980/03/01 by S. Morris Kupchan, David R. Streelman, Albert T. Sneden · 2 citations
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · #Natural Compound Pharmacology Studies #Ginseng Biological Effects and Applications #Phytochemistry and biological activity of medicinal plants
paper · doi:10.1021/np50008a010
openalex publication_date 1980/03/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/11
An ethanolic extract of Psorospermum febrifugum was fractionated with antileukemic activity in vivo in the P388 lymphocytic leukemia in mice and in vitro in the KB cell culture system used as a guide. The new antileukemic xanthone psorospermin 1 was isolated, and its structure was elucidated. The chlorohydrin of O-methylpsorospermin 2 was also isolated after treatment of the fraction containing psorospermin chlorohydrin 6 with diazomethane. Psorospermin 1 was demonstrated to have significant antitumor activity in the P388 in vivo system as well as cytotoxicity against the KB in vitro system.