2006/05/23 by Leonor Saiz, Jose M. G. Vilar, José M. G. Vilar · 1 citation
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #Bacterial Genetics and Biotechnology #CRISPR and Genetic Engineering #DNA and Nucleic Acid Chemistry #cond-mat.soft #physics.bio-ph #q-bio.BM #q-bio.SC
paper · pdf · doi:10.1016/j.sbi.2006.05.008
published as Curr. Opin. Struct. Biol. 16, 344-350 (2006)
openalex publication_date 2006/05/23 · arxiv created 2006/09/26 · arxiv updated 2009/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
The formation of DNA loops by proteins and protein complexes is ubiquitous to many fundamental cellular processes, including transcription, recombination, and replication. Here we review recent advances in understanding the properties of DNA looping in its natural context and how they propagate to the cellular behavior through gene regulation. The results of connecting the molecular properties with cellular physiology indicate that looping of DNA in vivo is much more complex and easier than predicted from current models and reveals a wealth of previously unappreciated details.