2006/10/02 by Georg Wuitschik, Mark Rogers‐Evans, Klaus Müller +5 · 1 citation
Pharmacology, Toxicology and Pharmaceutics · Chemistry · #Fluorine in Organic Chemistry #Synthesis and Catalytic Reactions #Click Chemistry and Applications
paper · doi:10.1002/anie.200602343
openalex publication_date 2006/10/02 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22
Ring the changes: Introduction of an oxetane ring results in remarkably improved physico- and biochemical properties of the underlying scaffold. The oxetane ring confers enhanced solubility, reduces the metabolic degredation, lipophilicity, and amphiphilicity, and modulates the basicity of a nearby amine group.