2012/09/23 by Adam Huczyński · 1 citation
Biochemistry, Genetics and Molecular Biology · #Biopolymer Synthesis and Applications #Cancer therapeutics and mechanisms #RNA Interference and Gene Delivery
paper · pdf · doi:10.1016/j.bmcl.2012.09.046
openalex publication_date 2012/09/23 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
The natural polyether ionophore antibiotics might be important chemotherapeutic agents for the treatment of cancer. In this article, the pharmacology and anticancer activity of the polyether ionophores undergoing pre-clinical evaluation are reviewed. Most of polyether ionophores have shown potent activity against the proliferation of various cancer cells, including those that display multidrug resistance (MDR) and cancer stem cells (CSC). The mechanism underlying the anticancer activity of ionophore agents can be related to their ability to form complexes with metal cations and transport them across cellular and subcellular membranes. Increasing evidence shows that the anticancer activity of polyether ionophores may be a consequence of the induction of apoptosis leading to apoptotic cell death, arresting cell cycle progression, induction of the cell oxidative stress, loss of mitochondrial membrane potential, reversion of MDR, synergistic anticancer effect with other anticancer drugs, etc. Continued investigation of the mechanisms of action and development of new polyether ionophores and their derivatives may provide more effective therapeutic drugs for cancer treatments.