2010/01/26 by Wayne K. Goodman, Ron L. Alterman · 1 citation
Medicine · Psychology · #Neurological disorders and treatments #Obsessive-Compulsive Spectrum Disorders #Parkinson's Disease Mechanisms and Treatments
paper · doi:10.1146/annurev-med-052209-100401
openalex publication_date 2010/01/26 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/15
Deep brain stimulation (DBS) has virtually replaced ablative neurosurgery for use in medication-refractory movement disorders. DBS is now being studied in severe psychiatric conditions, such as treatment-resistant depression (TRD) and intractable obsessive-compulsive disorder (OCD). Effects of DBS have been reported in ∼100 cases of OCD and ∼50 cases of TRD for seven (five common) anatomic targets. Although these published reports differ with respect to study design and methodology, the overall response rate appears to exceed 50% in OCD for some DBS targets. In TRD, >50% of patients responded during acute and long-term bilateral electrical stimulation in a different target. DBS was generally well tolerated in both OCD and TRD, but some unique, target- and stimulation-specific adverse effects were observed (e.g., hypomania). Further research is needed to test the efficacy and safety of DBS in psychiatric disorders, compare targets, and identify predictors of response.