An RNA foldability metric; implications for the design of rapidly foldable RNA sequences

2005/12/02 by Wilfred Ndifon, W. Ndifon, Asamoah Nkwanta +1
Biochemistry, Genetics and Molecular Biology · Environmental Science · Physics and Astronomy · #Bacterial Genetics and Biotechnology #Bacteriophages and microbial interactions #RNA and protein synthesis mechanisms #physics.bio-ph #q-bio.BM

paper · pdf · doi:10.1016/j.bpc.2005.11.012

To appear in Biophysical Chemistry

arxiv created 2005/12/02 · openalex publication_date 2006/01/07 · arxiv updated 2009/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

Evidence is presented suggesting, for the first time, that the protein foldability metric sigma=(T_theta - T_f)/T_theta, where T_theta and T_f are, respectively, the collapse and folding transition temperatures, could be used also to measure the foldability of RNA sequences. The importance of sigma is discussed in the context of the in silico design of rapidly foldable RNA sequences.

Citations

• A complex adaptive systems approach to the kinetic folding of RNA