2008/12/31 by Annie Lannuzel, Patrick P. Michel · 1 citation
Medicine · Neuroscience · #Parkinson's Disease Mechanisms and Treatments #Neurological diseases and metabolism #Lysosomal Storage Disorders Research
paper · doi:10.1007/978-1-60327-252-0_18
openalex publication_date 2008/12/31 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04
This chapter describes the phenotypic and clinical features of an atypical parkinsonian syndrome endemic to the Caribbean island of Guadeloupe. The clinical entity was much more frequent than idiopathic Parkinson’s disease. It corresponded to a unique combination of levodopa-resistant parkinsonism, tremor, myoclonus, hallucinations, REM sleep behavior disorder and fronto-subcortical dementia. Epidemiological and experimental studies suggested that the neurological syndrome resulted from chronic intoxication by a mitochondrial complex I inhibitor, the plant toxin annonacin.