Rabe Rest in Peace: Confirmation of the Rabe–Kindler Conversion of d‐Quinotoxine Into Quinine: Experimental Affirmation of the Woodward–Doering Formal Total Synthesis of Quinine

2008/01/31 by Aaron Smith, Robert M. Williams · 1 citation
Chemistry · #Asymmetric Synthesis and Catalysis #Chemical synthesis and alkaloids #Oxidative Organic Chemistry Reactions

paper · pdf · doi:10.1002/anie.200705421

openalex publication_date 2008/01/31 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/01

Abstract

Put to rest: The three-step conversion of d-quinotoxine into quinine, as originally reported by Rabe and Kindler in 1918, has been experimentally verified. This conversion serves to reaffirm the formal total synthesis of quinine reported by Woodward and Doering in 1944.

Citations

• The First Stereoselective Total Synthesis of Quinine
• The Total Synthesis of Quinine
• THE TOTAL SYNTHESIS OF QUININE1

Cited by

• Quinine total synthesis [wikipedia]