2010/11/11 by Volodymyr Babin, Christopher Roland, Celeste Sagui · 1 citation
Biochemistry, Genetics and Molecular Biology · Materials Science · Medicine · #Alzheimer's disease research and treatments #Enzyme Structure and Function #Protein Structure and Dynamics
paper · doi:10.1002/prot.22935
openalex publication_date 2010/11/11 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23
The α-sheet has been speculated to play a role as a toxic conformer in amyloid diseases. However, except for relatively short fragments, its detection has remained elusive. Here, we present molecular dynamics simulations that support the existence of the α-sheet as a stable, metastable, or long-lived secondary structure in polyglutamine and, to a lesser extent, in polyasparagine aggregates.