2006/10/30 by Aaron M. Kearney, Christopher D. Vanderwal · 2 citations
Chemistry · #Asymmetric Synthesis and Catalysis #Catalytic C–H Functionalization Methods #Synthesis and Catalytic Reactions
paper · doi:10.1002/anie.200602996
openalex publication_date 2006/10/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/26
The century-old ring-opening reaction of pyridinium salts with tethered nucleophiles has been harnessed for a synthesis of substituted indoles and related nitrogen heterocyles. Extension of this method could lead to oxygen- and sulfur-containing heterocycles and carbocycles, as well as to applications in natural product synthesis and medicinal chemistry.