A Stereoselective Synthesis oftrans-1,2-Disubstituted Alkenes Based on the Condensation of Aldehydes with Metallated 1-Phenyl-1H-tetrazol-5-yl Sulfones

1998/01/01 by Paul R. Blakemore, W.J. Cole, Philip Kocieński +1 · 2 citations
Chemistry · #Synthesis of Tetrazole Derivatives #Sulfur-Based Synthesis Techniques

paper · doi:10.1055/s-1998-1570

openalex publication_date 1998/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04

Abstract

All articles of this category The reaction of metallated 1-phenyl-1 H -tetrazol-5-yl sulfones and aldehydes gives good yields and stereoselectivity of trans -1,2-disubstituted alkenes when potassium or sodium hexamethyldisilazide is used as base and 1,2-dimethoxyethane is used as solvent. alkene synthesis - heterocyclic sulfones - aldehydes - Julia olefination - tetrazole - benzothiazole

Cited by

• From Total Synthesis to Diverted Total Synthesis: Case Studies in the Amphidinolide Series
• Julia olefination [wikipedia]