2002/01/01 by Thorsten Bach, Aude Lemarchand · 2 citations
Chemistry · Biochemistry, Genetics and Molecular Biology · #Synthetic Organic Chemistry Methods #Chemical Synthesis and Analysis #Synthesis and Biological Evaluation
paper · doi:10.1055/s-2002-32958
openalex publication_date 2002/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/11
The α,β,γ,δ-unsaturated 2,4,5-trimethoxyanilides 8a-e which bear a terminal alkenyl side chain at the 3-position were prepared from 1,2,4-trimethoxybenzene (2) in four steps and 25-41% overall yield. Attempted ring closing metathesis reactions were successful in the presence of catalysts 9 for the substrates 8c-e and led to the products 10c-e (66-91% yield). Substrates 8a and 8b with a shorter alkenyl side chain did not cyclize.