2006/08/21 by Ana Gradillas, Javier Pérez‐Castells · 8 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Advanced Synthetic Organic Chemistry #Chemical Synthesis and Analysis #Synthetic Organic Chemistry Methods
paper · doi:10.1002/anie.200600641
openalex publication_date 2006/08/21 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/15
The construction of macrocycles by ring-closing metathesis (RCM) is often used as the key step in the synthesis of natural products containing large rings. This reaction is attractive because of its high functional group compatibility and the possibility for further transformations. The finding of suitable reaction conditions is critical for the success of the synthesis. In this Minireview we summarize the efforts of many research groups to develop efficient RCM reactions on their way towards the total synthesis of natural macrocyclic products. Their findings should help in future synthesis to reduce the time-consuming phase of the optimization of the reaction conditions.