2003/09/19 by Carolyn E. Anderson, Larry E. Overman · 2 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Chemical Synthesis and Analysis #Asymmetric Hydrogenation and Catalysis #Chemical Synthesis and Reactions
paper · doi:10.1021/ja037086r
openalex publication_date 2003/09/19 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/26
COP-Cl catalyzes the rearrangement of (E)-allylic trichloroacetimidates to provide transposed allylic trichloroacetamides of high enantiopurity, a transformation that underlies the first truly practical method for transforming prochiral allylic alcohols to enantioenriched allylic amines and congeners. The high functional group compatibility of this asymmetric rearrangement and the demonstrated broad utility in synthesis of the allylic trichloroacetimidate to allylic trichloroacetamide conversion are singular features of this new catalytic asymmetric reaction.