In Water or in the Presence of Water?

2006/11/17 by Yujiro Hayashi · 4 citations
Chemical Engineering · Chemistry · #Asymmetric Synthesis and Catalysis #Chemical synthesis and alkaloids #Ionic liquids properties and applications

paper · doi:10.1002/anie.200603378

openalex publication_date 2006/11/17 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/16

Abstract

What expression best conveys the recent examples of “aqueous” organocatalyzed aldol reactions? It is suggested that a reaction occurs “in water” if the participating reactants are dissolved homogeneously in water (or buffer), or “in the presence of water” if it proceeds in a concentrated organic phase with water present as a second phase that influences the reaction in the former.

Cited by

• Water in Organocatalytic Processes: Debunking the Myths
• Organic Synthesis “On Water”
• Are Oxazolidinones Really Unproductive, Parasitic Species in Proline Catalysis? – Thoughts and Experiments Pointing to an Alternative View
• On-water reaction [wikipedia]