2005/06/09 by Friedrich Mühlthau, O. Schuster, Thorsten Bach · 2 citations
Chemistry · #Chemical Reaction Mechanisms #Organic and Inorganic Chemical Reactions #Coordination Chemistry and Organometallics
paper · doi:10.1021/ja050626v
openalex publication_date 2005/06/09 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/26
Chiral carbenium ions can be attacked by arene nucleophiles with high facial diastereoselectivity (dr >/= 94/6). Benzylic cations, such as 2, were generated under acidic conditions and reacted with arenes in intra- and intermolecular Friedel-Crafts alkylation reaction. The depicted reaction 1 --> 3 represents one example for the unprecedented, highly diastereoselective intermolecular Friedel-Crafts alkylation reactions which were observed in this study.