2007/09/14 by John C. Walton, Fernando Portela‐Cubillo · 1 citation
Chemistry · #Autoxidation #Benzene #Catalysis #Chemical synthesis and alkaloids #Chemistry #Cyclization and Aryne Chemistry #Ether #Flammable liquid #Hypervalent molecule #Medicinal chemistry #Organic and Inorganic Chemical Reactions #Organic chemistry #Reagent #Solubility
paper · doi:10.1002/047084289x.rn00806
openalex publication_date 2007/09/14 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/29
[628-41-1] C6H8 (MW 80.13) InChI = 1S/C6H8/c1-2-4-6-5-3-1/h1-2,5-6H,3-4H2 InChIKey = UVJHQYIOXKWHFD-UHFFFAOYSA-N (reagent used for removal of functional groups by catalytic transfer hydrogenation, and as a hydrogen-atom donor in radical reactions and enediyne type cycloaromatizations) Physical Data: mp – 49.2 °C; bp 88 °C; d 0.847 g cm−3. Solubility: sol hydrocarbons, ether, and most organic solvents. Form Supplied in: colourless liquid; widely available. Purification: dried over MgSO4 and fractionally distilled at 760 mmHg. High purity material can be obtained by removing traces of benzene by preparative GC. Handling, Storage, and Precautions: 1,4-cyclohexadiene is volatile and highly flammable (fp – 6 °C). To help prevent autoxidation, store under nitrogen, and refrigerate. It is a cancer suspect agent and should only be used in a well-ventilated fume hood.