2011/09/01 by Xiaoke Chen, Mariano I. Gabitto, Yueqing Peng +2 · 3 citations
Nursing · Neuroscience · Engineering · #Biochemical Analysis and Sensing Techniques #Olfactory and Sensory Function Studies #Advanced Chemical Sensor Technologies
paper · doi:10.1126/science.1204076
openalex publication_date 2011/09/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
The taste system is one of our fundamental senses, responsible for detecting and responding to sweet, bitter, umami, salty, and sour stimuli. In the tongue, the five basic tastes are mediated by separate classes of taste receptor cells each finely tuned to a single taste quality. We explored the logic of taste coding in the brain by examining how sweet, bitter, umami, and salty qualities are represented in the primary taste cortex of mice. We used in vivo two-photon calcium imaging to demonstrate topographic segregation in the functional architecture of the gustatory cortex. Each taste quality is represented in its own separate cortical field, revealing the existence of a gustotopic map in the brain. These results expose the basic logic for the central representation of taste.