Mendelian randomization of genetically independent aging phenotypes identifies LPA and VCAM1 as biological targets for human aging

2021/01/14 by Prhj Timmers, ES Tiys, Saori Sakaue +14 · 1 voice · 1 citation
Biochemistry, Genetics and Molecular Biology · Computer Science · Pharmacology, Toxicology and Pharmaceutics · #Ageing #Biology #Computational Drug Discovery Methods #Computational biology #Gene #Genetics #Mendelian inheritance #Nutrition, Genetics, and Disease #Pharmacogenetics and Drug Metabolism #Phenotype

paper · doi:10.7488/ds/2972

openalex publication_date 2021/01/14 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/01

Abstract

Genome-wide association summary statistics supporting the article Timmers et. al (2022) Nature Aging https://doi.org/10.1038/s43587-021-00159-8.

Citations

• Mendelian randomization of genetically independent aging phenotypes identifies LPA and VCAM1 as biological targets for human aging

Cited by

• Mendelian randomization of genetically independent aging phenotypes identifies LPA and VCAM1 as biological targets for human aging

Discussions

• We combined genetic studies of #healthspan, father and mother #lifespan, exceptional #longevity, #frailty, and self-rated health to create an underlying latent #aging trait (aging-GIP1). As always, [bsky, 0 points, 1 comments]

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