2023/12/01 by Li Li, Akshay N. Rana, Esther M. Li +3 · 1 voice
Neuroscience · #Functional Brain Connectivity Studies #Neural dynamics and brain function #Neuroscience and Neuropharmacology Research
paper · pdf · doi:10.1016/j.celrep.2023.113566
openalex publication_date 2023/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Catecholamine signaling is thought to modulate cognition in an inverted-U relationship, but the mechanisms are unclear. We measured norepinephrine and dopamine release, postsynaptic calcium responses, and interactions between tonic and phasic firing modes under various stimuli and conditions. High tonic activity in vivo depleted catecholamine stores, desensitized postsynaptic responses, and decreased phasic transmission. Together, these findings provide a more complete understanding of the inverted-U relationship, offering insights into psychiatric disorders and neurodegenerative diseases with impaired catecholamine signaling.