2023/09/04 by Joseph Matheson, Ulises Hernández, Jason Bertram +1 · 1 voice
Biochemistry, Genetics and Molecular Biology · #Evolution and Genetic Dynamics #Genetic diversity and population structure #Genetic Associations and Epidemiology
paper · pdf · doi:10.1101/2023.09.01.555871
openalex publication_date 2023/09/04 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Abstract Each new human has an expected U d = 2-10 new deleterious mutations. Using a novel approach to capture complex linkage disequilibria from high U d using genome-wide simulations, we confirm that fitness decline due to the fixation of many slightly deleterious mutations can be compensated by rarer beneficial mutations of larger effect. The evolution of increased genome size and complexity have previously been attributed to a similarly asymmetric pattern of fixations, but we propose that the cause might be high U d rather than the small population size posited as causal by drift barrier theory. High within-population variance in relative fitness is an inevitable consequence of high U d ∼2-10 combined with inferred human deleterious effect sizes; two individuals will typically differ in fitness by 15-40%. The need to compensate for the deluge of deleterious mutations slows net adaptation (i.e. to the external environment) by ∼13%-55%. The rate of beneficial fixations is more sensitive to changes in the mutation rate than the rate of deleterious fixations is. As a surprising consequence of this, an increase (e.g. 10%) in overall mutation rate leads to faster adaptation; this puts to rest dysgenic fears about increasing mutation rates due to rising paternal age.