2024/03/22 by Monika Halat, Grzegorz Zając, Valery Andrushchenko +4 · 1 voice
Biochemistry, Genetics and Molecular Biology · Chemistry · Materials Science · #Molecular spectroscopy and chirality #Photosynthetic Processes and Mechanisms #Supramolecular Self-Assembly in Materials
paper · doi:10.1002/anie.202402449
openalex publication_date 2024/03/22 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Carotenoids tend to form supramolecular aggregates via non-covalent interactions where the chirality of individual molecules is amplified to the macroscopic level. We show that this can also be achieved for non-chiral carotenoid monomers interacting with polysaccharides. The chirality induction in canthaxanthin (CAX), caused by heparin (HP) and hyaluronic acid (HA), was monitored by chiroptical spectroscopy. Electronic circular dichroism (ECD) and Raman optical activity (ROA) spectra indicated the presence of multiple carotenoid formations, such as H- and J-type aggregates. This is consistent with molecular dynamics (MD) and density functional theory (DFT) simulations of the supramolecular structures and their spectroscopic response.