2024/05/06 by Saumya Agrawal, Andrey Buyan, Jessica Severin +26 · 1 voice
Biochemistry, Genetics and Molecular Biology · #Cancer-related molecular mechanisms research #RNA Research and Splicing #RNA and protein synthesis mechanisms
paper · pdf · doi:10.1371/journal.pone.0295971
openalex publication_date 2024/05/06 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
The human genome is pervasively transcribed and produces a wide variety of long non-coding RNAs (lncRNAs), constituting the majority of transcripts across human cell types. Some specific nuclear lncRNAs have been shown to be important regulatory components acting locally. As RNA-chromatin interaction and Hi-C chromatin conformation data showed that chromatin interactions of nuclear lncRNAs are determined by the local chromatin 3D conformation, we used Hi-C data to identify potential target genes of lncRNAs. RNA-protein interaction data suggested that nuclear lncRNAs act as scaffolds to recruit regulatory proteins to target promoters and enhancers. Nuclear lncRNAs may therefore play a role in directing regulatory factors to locations spatially close to the lncRNA gene. We provide the analysis results through an interactive visualization web portal at https://fantom.gsc.riken.jp/zenbu/reports/#F63DlncRNA.