Polygenic Risk Scores for Alcohol Involvement Relate to Brain Structure in Substance-Naïve Children: Results from the ABCD Study

2020/07/28 by Alexander S. Hatoum, Emma C. Johnson, David A. A. Baranger +3 · 1 voice
Medicine · Neuroscience · #Prenatal Substance Exposure Effects #Substance Abuse Treatment and Outcomes #Functional Brain Connectivity Studies

paper · pdf · doi:10.1101/2020.07.25.20162032

openalex publication_date 2020/07/28 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/14

Abstract

ABSTRACT In substance naïve children (n=3,013), polygenic risk score (PRS) for problematic alcohol use was associated with lower volume of the frontal pole and greater cortical thickness of the supramarginal gyrus. Several other areas showed nominal significance. These associations suggest that genetic liability to alcohol involvement may manifest as variability in brain structure prior to consumption of the first alcoholic drink and alter brain morphometry during the start of adolescence.

Citations

• High-resolution intersubject averaging and a coordinate system for the cortical surface
• Convergent Evidence for Predispositional Effects of Brain Gray Matter Volume on Alcohol Consumption

Discussions

• Interesting that @AlexanderHatoum previously saw that Supramarginal thickness correlates with genetic risk for probelmatic alcohol use in the ABCD sample https://doi.org/10.1101/2020.07.25.20162032 C [bsky, 0 points, 0 comments]