Subthalamic stimulation evoked cortical responses relate to motor performance in Parkinson's disease

2023/03/01 by Bahne H. Bahners, Rachel K. Spooner, Christian J. Hartmann +2 · 1 voice
Medicine · Neuroscience · #Neurological disorders and treatments #Neuroscience and Neural Engineering #Parkinson's Disease Mechanisms and Treatments

paper · pdf · doi:10.1016/j.brs.2023.02.014

openalex publication_date 2023/03/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established therapy for Parkinson's disease (PD) [1]. However, determining the optimal stimulation setting can be a time-consuming trial-and-error process. Thus, there is a need to define non-invasive biomarkers, for instance through the analysis of DBS-evoked cortical responses (CR) [2]. Previous studies indicate that CR with latencies of 2–10 ms – resulting from antidromic hyperdirect pathway activation – are higher for stimulation contacts that elicit a therapeutic effect [3].

Discussions

• Similar to this strategy, folks have mapped #evokedresponses to DBS using #MEG and #EEG, before. #MEG is similarly costly/scarce than #fMRI, and conventional #EEG may be cumbersome to mount (~1 hour t [bsky, 0 points, 1 comments]

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