2018/10/22 by Haiyang Li, Haonan Wang, Maofeng Jing +12 · 1 voice · 1 citation
Agricultural and Biological Sciences · Medicine · Biochemistry, Genetics and Molecular Biology · #Plant-Microbe Interactions and Immunity #Fungal Infections and Studies #Genomics and Phylogenetic Studies
paper · doi:10.7554/elife.40039
openalex publication_date 2018/10/22 · openalex created_date 2018/10/26 · openalex updated_date 2026/07/28
Oomycete pathogens secrete host cell-entering effector proteins to manipulate host immunity during infection. We previously showed that PsAvh52, an early-induced RxLR effector secreted from the soybean root rot pathogen, Phytophthora sojae, could suppress plant immunity. Here, we found that PsAvh52 is required for full virulence on soybean and binds to a novel soybean transacetylase, GmTAP1, in vivo and in vitro. PsAvh52 could cause GmTAP1 to relocate into the nucleus where GmTAP1 could acetylate histones H2A and H3 during early infection, thereby promoting susceptibility to P. sojae. In the absence of PsAvh52, GmTAP1 remained confined to the cytoplasm and did not modify plant susceptibility. These results demonstrate that GmTAP1 is a susceptibility factor that is hijacked by PsAvh52 in order to promote epigenetic modifications that enhance the susceptibility of soybean to P. sojae infection.