2015/01/01 by Vinicius Barbosa de Souza, Eduardo Nani Silva, Mario Luiz Ribeiro +2
Medicine · #Cancer survivorship and care #Cancer, Stress, Anesthesia, and Immune Response #Chemotherapy-induced cardiotoxicity and mitigation
paper · doi:10.5935/abc.20150011
crossref issued 2015/01/01 · crossref published 2015/01/01 · crossref published-print 2015/01/01 · openalex publication_date 2015/01/01 · crossref created 2015/01/29 · crossref deposited 2021/03/05 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/03 · crossref indexed 2026/08/03
There is a known association between chemotherapy and radiotherapy for treatment of cancer patients and development or worsening of hypertension. The aim of this article is to review this association. A literature search was conducted for articles reporting this association on the databases PubMed, SciELO and LILACS between 1993 and 2013. There was a high coprevalence of hypertension and cancer, since both diseases share the same risk factors, such as sedentary lifestyle, obesity, smoking, unhealthy diet and alcohol abuse. The use of chemotherapy and adjuvant drugs effective in the treatment of cancer increased the survival rate of these patients and, consequently, increased the incidence of hypertension. We described the association between the use of angiogenesis inhibitors (bevacizumab, sorafenib and sunitinib), corticosteroids, erythropoietin and non-steroidal anti-inflammatory drugs with the development of hypertension. We also described the relationship between hypertension and carotid baroreceptor injury secondary to cervical radiotherapy. Morbidity and mortality increased in patients with cancer and hypertension without proper antihypertensive treatment. We concluded that there is need for early diagnosis, effective monitoring and treatment strategies for hypertension in cancer patients in order to reduce cardiovascular morbidity and mortality.