Inhibition of SRGAP2 Function by Its Human-Specific Paralogs Induces Neoteny during Spine Maturation

2012/05/01 by Cécile Charrier, Kaumudi Joshi, Jaeda Coutinho-Budd +12 · 1 voice · 6 citations
Biochemistry, Genetics and Molecular Biology · #Congenital heart defects research #Genomic variations and chromosomal abnormalities #Genomics and Chromatin Dynamics

paper · pdf · doi:10.1016/j.cell.2012.03.034

crossref issued 2012/05/01 · crossref published 2012/05/01 · crossref published-print 2012/05/01 · openalex publication_date 2012/05/01 · crossref created 2012/05/03 · crossref deposited 2025/09/25 · openalex created_date 2025/10/10 · crossref indexed 2026/07/31 · openalex updated_date 2026/08/01

Cited by

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Discussions

• What are the underlying molecular mechanisms? One candidate is the SRGAP2 gene family. Ectopic expression of human-specific SRGAP2B/C genes in mouse neurons led to delayed synaptic maturation and incr [bsky, 0 points, 1 comments]