2021/02/25 by Kelsey R. Babcock, JOHN S. PAGE, Justin R. Fallon +1 · 1 voice
Medicine · Neuroscience · #Alzheimer's disease research and treatments #Dementia and Cognitive Impairment Research #Neurogenesis and neuroplasticity mechanisms
paper · pdf · doi:10.1016/j.stemcr.2021.01.019
openalex publication_date 2021/02/25 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04
Cognitive deficits associated with Alzheimer's disease (AD) severely impact daily life for the millions of affected individuals. Progressive memory impairment in AD patients is associated with degeneration of the hippocampus. The dentate gyrus of the hippocampus, a region critical for learning and memory functions, is a site of adult neurogenesis in mammals. Recent evidence in humans indicates that hippocampal neurogenesis likely persists throughout life, but declines with age and is strikingly impaired in AD. Our understanding of how neurogenesis supports learning and memory in healthy adults is only beginning to emerge. The extent to which decreased neurogenesis contributes to cognitive decline in aging and AD remains poorly understood. However, studies in rodent models of AD and other neurodegenerative diseases raise the possibility that targeting neurogenesis may ameliorate cognitive dysfunction in AD. Here, we review recent progress in understanding how adult neurogenesis is impacted in the context of aging and AD.