2015/08/14 by Patrick L. Purdon, Aaron L. Sampson, Kara J. Pavone +1 · 1 voice · 3 citations
Medicine · Neuroscience · #Anesthesia and Neurotoxicity Research #Anesthesia and Sedative Agents #Intensive Care Unit Cognitive Disorders
paper · pdf · doi:10.1097/aln.0000000000000841
openalex publication_date 2015/08/14 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/04
AbstractAbstract The widely used electroencephalogram-based indices for depth-of-anesthesia monitoring assume that the same index value defines the same level of unconsciousness for all anesthetics. In contrast, we show that different anesthetics act at different molecular targets and neural circuits to produce distinct brain states that are readily visible in the electroencephalogram. We present a two-part review to educate anesthesiologists on use of the unprocessed electroencephalogram and its spectrogram to track the brain states of patients receiving anesthesia care. Here in part I, we review the biophysics of the electroencephalogram and the neurophysiology of the electroencephalogram signatures of three intravenous anesthetics: propofol, dexmedetomidine, and ketamine, and four inhaled anesthetics: sevoflurane, isoflurane, desflurane, and nitrous oxide. Later in part II, we discuss patient management using these electroencephalogram signatures. Use of these electroencephalogram signatures suggests a neurophysiologically based paradigm for brain state monitoring of patients receiving anesthesia care. The authors review the neurophysiology of the electroencephalogram signatures of the anesthetics: propofol, dexmedetomidine, ketamine, sevoflurane, isoflurane, desflurane, and nitrous oxide. These signatures provide a neurophysiologically based paradigm for brain state monitoring of patients receiving anesthesia care.