A cross-disease resource of living human microglia identifies disease-enriched subsets and tool compounds recapitulating microglial states

2024/10/15 by John F. Tuddenham, Mariko Taga, Verena Haage +38 · 1 voice · 1 citation
Immunology and Microbiology · Neuroscience · #Atherosclerosis and Cardiovascular Diseases #Immune cells in cancer #Neuroinflammation and Neurodegeneration Mechanisms

paper · doi:10.1038/s41593-024-01764-7

crossref issued 2024/10/15 · crossref published 2024/10/15 · crossref published-online 2024/10/15 · openalex publication_date 2024/10/15 · crossref created 2024/10/15 · crossref published-print 2024/12/01 · openalex created_date 2025/10/10 · crossref deposited 2026/03/12 · openalex updated_date 2026/08/01 · crossref indexed 2026/08/04

Citations

• Statistical significance for genomewide studies
• THE GENERALIZATION OF ‘STUDENT'S’ PROBLEM WHEN SEVERAL DIFFERENT POPULATION VARLANCES ARE INVOLVED
• Gene Ontology: tool for the unification of biology
• Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease
• Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
• Microglia Heterogeneity in the Single-Cell Era
• Overview of General and Discriminating Markers of Differential Microglia Phenotypes
• diaPASEF: parallel accumulation–serial fragmentation combined with data-independent acquisition
• Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease
• Integrated analysis of multimodal single-cell data
• CellProfiler 4: improvements in speed, utility and usability
• A lymphocyte–microglia–astrocyte axis in chronic active multiple sclerosis

Cited by

• Human-specific SRGAP2 paralogs synchronize neotenic microglial maturation and synaptic development

Discussions

• My favorite paper this week. Why? It takes microglial profiling to another level beyond clusters. The authors identify disease-associated microglial subsets, show their classifications can be applied [bsky, 0 points, 0 comments]